reasoning benchmark
MedChemBench (Internal)
MedChemBench is an internal OpenAI evaluation of medicinal-chemistry reasoning, testing whether models can support drug-discovery-relevant chemistry analysis and decision-making.
Updated Aug 7, 2026
Published models3
Registry coverage3
MetricScore
EvidenceB
MedChemBench (Internal) leaderboard
Sorted by the source-provided rank. Higher score is better according to the registry.
| 1 | OP | 48.3% | 100.0% | 3 | C | |
| 2 | OP | 35.0% | 50.0% | 3 | C | |
| 3 | OP | 30.4% | 0.0% | 3 | C |
Score distribution
Top published rows on the benchmark's original scale.
MedChemBench (Internal) highlights
The top published results on this benchmark's own scale.
What is MedChemBench (Internal)?
Definition and scoring fields from the benchmark registry.
MedChemBench is an internal OpenAI evaluation of medicinal-chemistry reasoning, testing whether models can support drug-discovery-relevant chemistry analysis and decision-making.
Scores are shown in ratio. The current registry marks this benchmark as not independently verified with evidence level B.
- Family
- MedChemBench (Internal)
- Modality
- text
- Primary category
- reasoning
- Score direction
- higher
- LLMBoard eligible
- No
- Evaluation key
- medchembench|llm-stats-current
Source-native results are preserved. Eligibility for the overall LLMBoard score is a separate policy decision.
FAQ
Common questions about MedChemBench (Internal).
Which model scores highest on MedChemBench (Internal)?
GPT-5.6 Sol is currently ranked first with 48.3%.
What does MedChemBench (Internal) measure?
MedChemBench is an internal OpenAI evaluation of medicinal-chemistry reasoning, testing whether models can support drug-discovery-relevant chemistry analysis and decision-making.
Is a higher score better?
Yes. Higher values rank better for this benchmark.
How many models are compared?
3 unique published model results are currently shown.
Does this benchmark affect the overall score?
This benchmark is preserved as source-native evidence but is not eligible for the current overall score.